After defining and identifying treatment resistance and loss of response, it is time to look at second-line therapies. In this presentation, Dr. Bose and Dr. Kuykendall discuss available and emerging treatment strategies that may be implemented when patients fail to respond or lose response to ruxolitinib therapy. Additionally, these experts share recommendations and strategies for effectively transitioning from first- to second-line therapy.

Several JAK inhibitors are now approved for the treatment of myelofibrosis (MF). Ruxolitinib is considered the standard of care for managing symptomatic MF and, as such, is most often used in the frontline treatment setting. Peer-reviewed literature reflects the pervasive use of ruxolitinib in the frontline MF setting, and the overwhelming majority of data available for study and review in these patients involves ruxolitinib. This data is clear: the majority of patients will either fail to respond or lose response to ruxolitinib over time. Treatment resistance and loss of response can be difficult to identify and define. In this activity, two experts describe risk factors for disease progression, review methods of assessing for and identifying resistance, and how to manage treatment failure.

Join Dr. Spivak as he discusses risk stratification and management strategies for polycythemia vera (PV). Topics include the pathophysiology and mutational foundation of PV, predicting risk and PV prognosis, current treatment strategies and controversies, and the role of targeted therapies in managing PV.

Join Dr. Mascarenhas as he discusses new and emerging treatment approaches for relapsed/refractory myelofibrosis (MF). Topics include a review of the COMFORT-1 and -2 and the JAKARTA2 trials of ruxolitinib and fedratinib, and recently released outcomes of trials evaluating investigational agents such as momelotinib, pacritinib, navitoclax, pelabresib, and imetelstat.

Join Dr. Mesa as he discusses new opportunities for JAK inhibitors in myelofibrosis (MF). Topics will include the ruxolitinib phase 3 COMFORT I and II trials, management of early-onset treatment-associated cytopenia, and outcomes associated with fedratinib in the JAKARTA and JAKARTA-2 trials

In this activity, Dr. Srdan Verstovsek will discuss management of myelofibrosis-associated anemia. He will provide guidance on thresholds for red blood cell transfusion, criteria for selecting anemia therapy, and current and emerging treatment options for managing anemia, including erythropoiesis-stimulating agents (ESAs), anabolic steroids, corticosteroids, immunomodulatory agents, Janus kinase (JAK) inhibitors, anti-hemojuvelin antibodies, ALK2 receptor inhibitors, and luspatercept.

Explore new data on MPN presented at the 2020 ASH Annual meeting. In this activity, experts will discuss long-term outcomes of the CONTINUATION-PV trial comparing ropegylated interferon versus hydroxyurea; phase 2 study results of idasanutlin as second-line therapy; the efficacy of PTG-300 for anemia; results from the SIMPLIFY-2 study of momelotinib; data on CPI-0610; outcomes of imetelstat in high-risk patients; navitoclax in relapsed/refractory myelofibrosis; and the potential utility of the LSD1 inhibitor bomedemstat (IMG-7289).

This activity was previously presented as a live webinar with Q&A on March 08, 2021. Please note: If you participated in the live webinar, you are ineligible to receive an additional 1.0 contact hour of credit and may not re-submit for credit previously awarded.

Mutational testing is an integral part of the management of myeloproliferative neoplasms (MPNs), as results from this assessment can both guide treatment selection and provide prognostic information. In this article, Dr. Aaron Gerds discusses best practice regarding the utility of mutational testing in clinical practice when treating patients with MPNs.

Approaching management and diagnosis of a patient with polycythemia vera (PV) can be challenging. In this activity, Dr. Rampal explains the goals of therapy, prognostication of thrombosis, and therapies in first-line treatment. He also discusses the patient-related features to consider when developing a treatment plan.

Management of myeloproliferative neoplasms has evolved considerably since the identification of JAK2 and targeted therapy that has improved disease-related symptoms and quality of life. Our renowned faculty will provide updates in the latest data related to diagnosis, treatment options, guidelines, and standards of care through a highly interactive educational experience. Three real-life case scenarios will be presented, and the faculty will discuss treatment options and the journey of each patient.

This activity was previously presented as a webinar with live Q&A in September of 2020. Please note: If you participated in the live webinar, you are ineligible to receive an additional 1.25 contact hours of credit and may not re-submit for credit previously awarded.

The approval of ruxolitinib established JAK inhibitor therapy as the standard of care for intermediate- and high-risk myelofibrosis (MF), and the recent approval of fedratinib further supports the important role of JAK inhibitors in this setting. There is an urgent need for novel targeted therapies and new approaches. This article summarizes some of the most compelling data from key clinical trials investigating novel treatment approaches for MF and concludes with strategies to improve physician-patient communication.

It is well known that JAK/STAT signaling plays a central role in the pathogenesis of myelofibrosis (MF), and the demonstrated efficacy of the JAK inhibitor ruxolitinib in myelofibrosis has established it as standard of care in intermediate- and high-risk disease. Based on the success of ruxolitinib in this setting, other JAK inhibitors have been under investigation to further improve clinical outcomes in MF. The recent approval of fedratinib in both the frontline and second-line setting has expanded treatment options for MF, and pacritinib and momelotinib are also showing great promise in clinical trials. In this article, Dr. Elizabeth Hexner will review recent data supporting the role of JAK inhibitors for the treatment of MF.